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🔗 PC Part Picker

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PICK PARTS. BUILD YOUR PC. COMPARE AND SHARE.

We provide computer part selection, compatibility, and pricing guidance for do-it-yourself computer builders.

🔗 mdBook

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mdBook is a command line tool to create books with Markdown. It is ideal for creating product or API documentation, tutorials, course materials or anything that requires a clean, easily navigable and customizable presentation.

🔗 A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression

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A recent “umbrella” review examined various biomarkers relating to the serotonin system, and concluded there was no consistent evidence implicating serotonin in the pathophysiology of depression. We present reasons for why this conclusion is overstated, including methodological weaknesses in the review process, selective reporting of data, over-simplification, and errors in the interpretation of neuropsychopharmacological findings. We use the examples of tryptophan depletion and serotonergic molecular imaging, the two research areas most relevant to the investigation of serotonin, to illustrate this.