Fascinating review of the D switch which takes common drugs and substitutes one or more hydrogen atoms with deuterium. This leads to changes in the pharmacokinetic profile, often slowing down the metabolism of the drug.
CC Licensed free Psychopharmacology book with very nice illustrations. Useful study guide.
Clinical and research information on drug-induced liver injury.
Well this monster drug may be used with AIDS and is currently under trials for treating depression and many other inflammatory diseases. Due to it's anti-TNFα action.
A new antidepressant molecule called Amibegron by Sanofi-Aventis. The first β3-adrenoceptor agonist to cross the blood-brain barrier. No sexual side effects. Paper on its effects on rodents.
For those who are not in the biz, it may surprise you to learn that the FDA does not decide what a drug is indicated for. It only decides if the indication that Pharma chooses to request is approved or not. If Risperdal is approved for bipolar mania but not maintenance, it doesn't mean that it isn't safe and efficacious for maintenance; or that there isn't a huge collection of data affirming this. It means Janssen didn't ask the FDA for the approval. In other words, 95% of the decision for an indication is made by the folks down at Pharma marketing. All the FDA can do is say yes or no.
Methylene blue will be marketed by the name Rember. Supposedly it disentangles tau protein that suppresses normal neuronal functioning in Alzheimer's. Will be first drug to reverse the course of disease. Research still by pharma only.
List of drugs on the market .. a bit old but useful
SSRI brain zaps side effect phenomenon
damn interesting
one of the coolest Antidepressants featured on Wikipedia front page...link to a frozen snapshot of article.
chantix side effect: pleasurable vivid and memorable dreams
Lilly has spent .2 billion since 2004 to settle lawsuits from 28,500 people who claimed they developed diabetes or heart problems after taking the drug.
A Research Program Studying Treatment Effectiveness and Outcomes in Schizophrenia and Alzheimer’s Disease
suggest that the serotoninergic system may play a role in the pathophysiology of neuroleptic-induced akathisia
Review of the Pharmacology and Clinical Profile of Bupropion, an Antidepressant and Tobacco Use Cessation Agent
Schematic diagram of the human brain that highlights some of the main brain areas and neurotransmitter pathways implicated in reward processes.
effexor withdrawal
"the electric brain thing", "the Zaps", "Blips", "Effexor shocks" or "brain spasms", is a rare but notorious withdrawal symptom of SSRI
Data on the off-label usefulness of newer atypical antipsychotics are limited ...