Life is hard. Some days are at the absolute limit of what we can manage. Some days are worse than that. Eating—picking a meal, making it, putting it into your facehole—can feel like an insurmountable challenge. We wrote this cookbook to share our coping strategies. It has recipes to make when you've worked a 16-hour day, when you can't stop crying and you don't know why, when you accidentally woke up an Eldritch abomination at the bottom of the ocean. But most of all, this cookbook exists to help Sad Bastards like us feel a little less alone at mealtimes.

A recent “umbrella” review examined various biomarkers relating to the serotonin system, and concluded there was no consistent evidence implicating serotonin in the pathophysiology of depression. We present reasons for why this conclusion is overstated, including methodological weaknesses in the review process, selective reporting of data, over-simplification, and errors in the interpretation of neuropsychopharmacological findings. We use the examples of tryptophan depletion and serotonergic molecular imaging, the two research areas most relevant to the investigation of serotonin, to illustrate this.

"The meta-analysis suggested that an increase in ambient PM2.5 concentration was strongly associated with increased depression risk in the general population, and the association appeared stronger at long-term lag and cumulative lag patterns, suggesting a potential cumulative exposure effect over time."

"as a psychiatrist, if I ever had the misfortune to develop severe depression, my treatment of choice would be electroconvulsive therapy (ECT)."

NotesCite this as: BMJ 2012;345:e6994

A moving read: "A letter to … my depressed husband who has left us"

The Ketamine for resistant bipolar depression trial.

Results showed there was a significant inverse correlation between severity of depression and distance of the lesion from the frontal pole among 163 patients with left hemisphere stroke but not among 106 patients with right hemisphere stroke. This study supports the hypothesis that risk of poststroke depression is related to the location of brain injury.

To establish the effects of depression per se, each task was first analyzed for the placebo-treated participants alone by group (depressed patients versus comparison subjects) as the between-subjects factor. For performance in the emotional categorization task and memory, valence (positive or negative) was an additional within-subjects factor. Next, the effects of the drug manipulation were assessed using analysis of variance with drug treatment (reboxetine or placebo) and group (depressed patients or comparison subjects) as between-subjects factors and emotion (positive or negative) as the within-subjects factor, as above. Statistically significant interactions were followed up with simple analyses for group differences.

10 question observer rating scale for depression.

"I write of melancholy, by being busy to avoid melancholy. There is no greater cause of melancholy than idleness, no better cure than business."

Cry too.

Comic based on the artist's life about depression.

Mild depressive symptoms can therefore be seen as a natural part of dealing with failure in young adulthood. They set in when a goal is identified as unreachable and lead to a decline in motivation. In this period of low motivation, energy is saved and new goals can be found. If this mechanism does not function properly, though, severe depression can be the consequence.

Ellen had revenge fantasies toward her husband, Max, because she held him responsible for the accidental death of their 10-year-old son, Morgan. Instead of taking Morgan to ski on an intermediate slope as planned, Max had impulsively selected an advanced slope. Morgan hit a tree and later died of a head injury.

Through this process I have discovered a deeper level of compassion. It is a compassion rooted in the real world, and it includes myself. I realized that the compassion I used to have was detached and aloof. I was at the same time disconnected from patients yet overinvested in them. My aloofness and disconnectedness also caused a degree of social ineptitude and a lack of perception that made me capable at times of being a jerk to peers and co-workers. I am more self-possessed now and more genuinely connected with other people.

The mental health services in Egypt today are described, and transcultural studies carried out in Egypt of the prevalence and phenomenology of anxiety, schizophrenia, depression, suicide, conversion and obsessive compulsive disorders are reviewed. The psychiatric services for children are in their infancy. Since 1983 the common and semi-accepted use of hashish has been joined by abuse by heroin and other substances.

When your friends are your references.

أن ابنه المتوفي، كان يعاني حالة اكتئاب شديدة، وكشف عن أنه ترك خطاباً بخط يده قال فيه: إنه قرر الانتحار بإلقاء نفسه من فوق سطح المنزل، لضيقه م

next generation TMS

depression

Data on the off-label usefulness of newer atypical antipsychotics are limited ...